期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 73, 期 -, 页码 491-537出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.73.011303.074043
关键词
N-glycans; O-glycans; O-fucose; O-mannose; glycosaminoglycans; glycosphingolipids
资金
- NCI NIH HHS [1PO1-CA71932] Funding Source: Medline
- NIGMS NIH HHS [GM48666, GM62116, R01 GM061126] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA071932] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM048666, R01GM061126, U54GM062116] Funding Source: NIH RePORTER
Researchers have long predicted that complex carbohydrates on cell surfaces would play important roles in developmental processes because of the observation that specific carbohydrate structures appear in specific spatial and temporal patterns throughout development. The astounding number and complexity of carbohydrate structures on cell surfaces added support to the concept that glycoconjugates would function in cellular communication during development. Although the structural complexity inherent in glycoconjugates has slowed advances in our understanding of their functions, the complete sequencing of the genomes of organisms classically used in developmental studies (e.g., mice, Drosophila melanogaster, and Caenorhabditis elegans) has led to demonstration of essential functions for a number of glycoconjugates in developmental processes. Here we present a review of recent studies analyzing function of a variety of glycoconjugates (O-fucose, O-mannose, N-glycans, mucin-type O-glycans, proteoglycans, glycosphingolipids), focusing on lessons learned from human disease and genetic studies in mice, D. melanogaster, and C. elegans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据