期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
卷 20, 期 -, 页码 61-86出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.20.012103.135836
关键词
chalone; TGF-beta family; satellite cell; myoblast; latency
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD035887] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R01CA088866] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA 88866] Funding Source: Medline
- NICHD NIH HHS [R01 HD 35887] Funding Source: Medline
Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle mass. During embryogenesis, myostatin is expressed by cells in the myotome and in developing skeletal muscle and acts to regulate the final number of muscle fibers that are formed. During adult life, myostatin protein is produced by skeletal muscle, circulates in the blood, and acts to limit muscle fiber growth. The existence of circulating tissue-specific growth inhibitors of this type was hypothesized over 40 years ago to explain how sizes of individual tissues are controlled. Skeletal muscle appears to be the first example of a tissue whose size is controlled by this type of regulatory mechanism, and myostatin appears to be the first example of the long-sought chalone.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据