期刊
NEUROSIGNALS
卷 13, 期 3, 页码 99-113出版社
KARGER
DOI: 10.1159/000076563
关键词
Axin, biological function; Axin identification; Axin/JNK signaling pathway; Wnt pathway
Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. It is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by down-regulating the beta-catenin levels. Recently, it was demonstrated that Axin also plays an important role in a JNK signaling pathway. Axin utilizes discriminatory domains for its distinct roles in the Wnt pathway and in the Axin/JNK pathway. Here we review the data that show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis. Copyright (C) 2004 S. Karger AG, Basel.
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