期刊
HUMAN REPRODUCTION UPDATE
卷 10, 期 1, 页码 3-18出版社
OXFORD UNIV PRESS
DOI: 10.1093/humupd/dmh002
关键词
Angelman syndrome; assisted reproductive technology; Beckwith-Wiedemann syndrome; genomic imprinting; reproduction
Recent studies suggest a possible link between human assisted reproductive technology and genomic imprinting disorders. Assisted reproductive technology includes the isolation, handling and culture of gametes and early embryos at times when imprinted genes are likely to be particularly vulnerable to external influences. Evidence of sex-specific differences in imprint acquisition suggests that male and female germ cells may be susceptible to perturbations in imprinted genes at specific prenatal and postnatal stages. Imprints acquired first during gametogenesis must be maintained during preimplantation development when reprogramming of the overall genome occurs. In this review, we will discuss both new developments in our understanding of genomic imprinting including the mechanisms and timing of imprint erasure, acquisition and maintenance during germ cell development and early embryogenesis as well as the implications of this research for future epigenetic studies in reproduction and assisted reproductive technology.
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