期刊
CATALYSIS LETTERS
卷 143, 期 3, 页码 298-301出版社
SPRINGER
DOI: 10.1007/s10562-013-0962-1
关键词
Enzymatic catalysis; Heterocycles; Cyclization; Multicomponent; Thiazolidinones
资金
- National Natural Science Foundation of China [21106026]
- Key Sci-tech Innovation Team of Zhejiang Province [2010R50017-7]
- HNUEYT [2011-01-13]
A facile enzymatic one-pot multicomponent synthesis of 4-thiazolidinones was developed. The trypsin from porcine pancreas displayed great catalytic activity to promote the reaction of aldehyde, amine and mercaptoacetic acid with high yields showing a broad substrate specificity in this reaction. This trypsin-catalyzed multicomponent conversion method provided a novel strategy to synthesize thiazolidinones and expanded the application of trypsin in organic synthesis. .
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