期刊
ANNUAL REVIEW OF IMMUNOLOGY
卷 22, 期 -, 页码 765-787出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.22.012703.104554
关键词
death; survival; naive; activated; memory
类别
资金
- NIAID NIH HHS [AI-52225, AI-22295, AI-18785, AI-17134] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI018785, R56AI017134, R01AI017134, P01AI022295, R37AI017134, R01AI052225, R01AI018785] Funding Source: NIH RePORTER
The factors affecting T cell viability vary depending on the type and status of the T cell involved. Naive T cells die via a Bcl-2/Bim dependent route. Their deaths are prevented in animals by IL-7 and contact with MHC. Activated T cells die in many different ways. Among these is a pathway involving signals that come from outside the T cell and affect it via surface receptors such as Fas. Activated T cells also die through a pathway driven by signals generated within the T cell itself, a cell autonomous route. This pathway involves members of the Bcl-2 family, in particular Bcl-2, Bcl-xl, Bim, and probably Bak. The viability of CD8+ and CD4+ memory T cells is controlled in different ways. CD8+ memory T cells are maintained by IL-15 and IL-7. The control of CD4+ memory T cells is more mysterious, with roles reported for IL-7 and/or contact via the TCR.
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