期刊
CATALYSIS LETTERS
卷 141, 期 6, 页码 872-876出版社
SPRINGER
DOI: 10.1007/s10562-011-0589-z
关键词
Valine; Dipeptide; Aldol reaction; Brine
资金
- National Natural Science Foundation of China [20802025]
- Jilin Provincial Science & Technology Sustentation Program [20090585, 20100538]
A series of valine dipeptide organocatalysts containing a primary amine group and two amide units have been developed and evaluated in the direct asymmetric intermolecular aldol reaction of 4-nitrobenzaldehyde and cyclohexanone. When 2,4-dinitrophenol (DNP) was used as an acidic additive, the catalyzed reactions of various aldehydes and ketones gave the corresponding aldol products with moderate to high enantioselectivities (up to 95%) and diastereoselectivities (up to > 99/1, anti/syn) in the presence of 3c in brine.
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