期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 32, 期 1, 页码 36-40出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200401000-00008
关键词
aging; skeletal muscle; excitation-contraction coupling; denervation
资金
- NIA NIH HHS [AG18755, AG13934, AG15820] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG015820, R01AG018755, R01AG013934, R29AG013934] Funding Source: NIH RePORTER
Excitation-contraction (EC) uncoupling is a major cause of decreased muscle force generating capacity (specific force). However, the underlying mechanisms of EC uncoupling in muscle from aging mammals have not been characterized. We propose that impaired motor neuron function with aging leading to muscle denervation, a process probably initiated earlier than detected by in vitro morphologic techniques, results in EC uncoupling.
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