期刊
DEVELOPMENTAL NEUROSCIENCE
卷 26, 期 2-4, 页码 229-244出版社
KARGER
DOI: 10.1159/000082140
关键词
ganglionic eminence; dopamine; cell cycle; striatum; prefrontal cortex; D-1 receptor; D-2 receptor
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD005515] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043426] Funding Source: NIH RePORTER
- NICHD NIH HHS [HD 05515, P01 HD005515] Funding Source: Medline
- NINDS NIH HHS [R01 NS043426, NS 43426] Funding Source: Medline
Dopamine and its receptor binding sites appear in the brain early in the embryonic period raising the possibility that dopamine may influence brain development. We show that one component of dopamine's role in brain development is its ability to influence proliferation and differentiation of progenitor cells in the neostriatum and the dorsomedial prefrontal cortex on embryonic day 15 in mice. Dopamine and a D-1-like receptor agonist reduce the relative proportion of progenitor cells incorporating the S phase marker bromodeoxyuridine. A D-2-like agonist produces the opposite effect. Both the effects are evident in the lateral ganglionic eminence, neuroepithelial precursor of the neostriatum and in the neuroepithelium of the dorsomedial prefrontal cortex. Neostriatal progenitor cells are more responsive than cortical progenitor cells to the effects of dopamine receptor activation. Furthermore, progenitor cells in the ventricular zone are more responsive to D-1-like agonists and progenitors in the subventricular zone more so to D-2-like agonists. Thus, dopamine's developmental effects show regional and progenitor cell type specificity, presumably due to heterogeneity in the distribution of its receptor binding sites. Copyright (C) 2004 S. Karger AG, Basel.
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