期刊
ANNUAL REVIEW OF PHYSIOLOGY
卷 66, 期 -, 页码 625-645出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.66.032102.135749
关键词
lung development; tissue interactions; gene expression; growth factors
类别
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL056387, R01HL071898] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01HL071898, P50HL56387] Funding Source: Medline
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesodenn. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
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