期刊
EXPERIMENTAL LUNG RESEARCH
卷 30, 期 1, 页码 1-15出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140490252858
关键词
chronic obstructive pulmonary disease; cigarette smoke; emphysema; matrix metalloproteinase; smoking cessation
B6C3F(1) female mice were exposed to cigarette smoke (CS) (250 mg/m(3) total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes and matrix metalloproteinase (MMP)-2 and MMP-9 content in bronchoalveolar lavage fluid. Partial recovery of most lavage Parameters (except lymphocytes) was observed I week after cessation of CS exposure with further reductions after 4 weeks, but interstitial inflammation persisted longer. These results support a role for MMPs in CS-induced emphysema and indicate that smoking cessation allows restoration toward normal homeostasis.
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