期刊
DRUG DELIVERY
卷 11, 期 1, 页码 53-58出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10717540490265298
关键词
controlled release; diffusion; drug delivery; hydrogel; swelling interface number
Hydroxyethylmethacrylate/methacrylic acid copolymer crosslinked with ethylenglycol dimethacrylate was prepared by a bulk free radical polymerization method. The permeability studies of this pH-sensitive hydrogel to drugs with different water solubilities showed a water-content dependent diffusion or pore mechanism for ephedrine HCI (water-soluble model drug), whereas, a partition or solute-diffusion mechanism for indomethacin (a water-insoluble drug) was seen. Data analysis of release tests, according to the swelling interface number and Peppas equation for ephedrine HCI in pH 7.4, showed a biexponential model kinetic, whereas in pH 1.2 a swelling-controlled mechanism was seen. Indomethacin was released by an anomalous or non-Fickian release kinetics.
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