期刊
DEVELOPMENTAL NEUROSCIENCE
卷 26, 期 5-6, 页码 352-358出版社
KARGER
DOI: 10.1159/000082277
关键词
retina; eye; development; Wnts; Frizzleds
资金
- NATIONAL EYE INSTITUTE [R01EY014954, R01EY012274] Funding Source: NIH RePORTER
- NEI NIH HHS [EY012274, R01 EY014954, EY014954, R01 EY014954-02] Funding Source: Medline
Multiple signaling pathways are known to be involved in regulating development of the vertebrate neural retina. Recent publications have demonstrated that Wnt/Frizzled (Fz) signaling components are expressed in the developing retina and may play a fundamental role in retinogenesis. In this review, we summarize Wnt/Fz expression patterns in the developing vertebrate retina, mainly from chick and mouse, and compare them with Wnt/beta-catenin reporter activity. Consistent with the dynamic expression patterns of Wnt pathway components, evidence suggests that Wnt/Fz signaling has multiple roles during retinal development. Copyright (C) 2004 S. Karger AG, Basel.
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