期刊
ANNUAL REVIEW OF GENETICS
卷 38, 期 -, 页码 681-707出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.38.072902.092200
关键词
amyloid; [URE3]; [PSI]; [Het-s]; [PIN]; PrP
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [Z01DK024943] Funding Source: NIH RePORTER
Just as nucleic acids can carry out enzymatic reactions, proteins can be genes. These heritable infectious proteins (prions) follow unique genetic rules that enable their identification: reversible curing, inducible spontaneous generation, and phenotype surprises. Most prions are based on self-propagating amyloids, depend heavily on chaperones, show strain phenomena and, like other infectious elements, show species barriers to transmission. A recently identified prion is based on obligatory self-activation of an enzyme in trans. Although prions can be detrimental, they may also be beneficial to their hosts.
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