期刊
TUBERCULOSIS
卷 84, 期 3-4, 页码 263-274出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2003.12.005
关键词
Mycobacterium tuberculosis; innate drug resistance; microarray; isoniazid; isoxyl; tetrahydrolipstatin
资金
- Wellcome Trust Funding Source: Medline
The response of Mycobacterium tuberculosis to six anti-microbial agents was determined by microarray analysis in an attempt to define mechanisms of innate resistance in M. tuberculosis. The gene expression profiles of M. tuberculosis after treatment at the minimal inhibitory concentration (MIC) for 4h with isoniazid, isoxyl, tetrahydrolipstatin, SRI#221, SR1#967 and SR1#9190 were compared to untreated M. tuberculosis. A common response to drug exposure was defined, and this expression profile overlapped with a number of other mycobacterial stress responses recently identified by microarray analysis. Compound-specific responses were also distinguished including a number of putative transcriptional regulators and translocation-related genes. These genes may contribute to the intrinsic resistance of M. tuberculosis to anti-microbial compounds. Further investigation into these mechanisms may elucidate novel pathways contributing to mycobacterial drug resistance and influence anti-mycobacterial drug development strategies. (C) 2004 Elsevier Ltd. ALL rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据