期刊
CATALYSIS LETTERS
卷 124, 期 3-4, 页码 397-404出版社
SPRINGER
DOI: 10.1007/s10562-008-9492-7
关键词
asymmetric synthesis; direct aldol reaction; organocatalysis; proline derivatives; amphiphilic; water
资金
- Natural Science Foundation of China [20372059]
Two novel amphiphilic L-proline derivatives bearing long alkyl chain on the 4-position via ether bonds, 1a and 1b, have been synthesized and evaluated for the asymmetric direct aldol reaction in organic solvents as well as in water. The catalytic activities with 5 mol% of 1a are better than that of 30 mol% of proline itself being used. Especially, high yields (up to 99%), excellent enantioselectivities (up to 99% ee) and anti-diastereoselectivities (up to 99:1) are achieved in the reactions of aromatic aldehydes and cyclic ketones at room temperature with 5 mol% of 1a in water.
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