Highly efficient and scale-up synthesis of propargylamines catalyzed by graphene oxide-supported CuCl2 catalyst under microwave condition

An efficient, green and practical approach was developed to synthesize propargylamines using recyclable GO-CuCl2 via a one-pot multicomponent aldehyde-alkyne-amine (A(3)) coupling reaction. The propargylamines are readily obtained in good to excellent yields (85-96%) and on multi-gram scale (88%, 150 mmol) under microwave irradiation. GO-CuCl2 could be easily recovered through filtration and reused at least five recycles with no significant decreases in the yields. (C) 2014 Elsevier B.V. All rights reserved.