4.6 Article

Protease-catalyzed direct aldol reaction

期刊

CATALYSIS COMMUNICATIONS
卷 12, 期 7, 页码 580-582

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.catcom.2010.12.003

关键词

Enzyme catalysis; Alkaline protease; Enantioselectivity; Aldol reaction

资金

  1. Natural Science Foundation [2009BA5051]
  2. State Personnel Ministry

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A new function of BLAP (alkaline protease from Bacillus licheniformis) was first discovered to catalyze direct aldol reactions between aromatic aldehydes and cyclic ketones in an organic medium in the presence of water. The products were obtained in yields of 28-92% with 22-99% ee. (C) 2010 Elsevier B.V. All rights reserved.

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