期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 1, 页码 72-77出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.0301203
关键词
knockout mice; estrogen; receptor; growth plate; fusion
To determine the long-term role of ERbeta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ERbeta(-/-), ERalpha(-/-), and ERalpha(-/-)beta(-/-) mice. Our results show that ERbeta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates.
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