Mannich reactions catalyzed by perchloric acid in Triton X10 aqueous micelles

Perchloric acid can efficiently catalyze the one-pot, three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines in Triton X10 aqueous micelles at room temperature. This protocol has several advantages such as excellent yields, mild conditions, clear reaction profile and simple work-up procedure. (C) 2010 Elsevier B.V. All rights reserved.