期刊
MOLECULAR BIOLOGY OF THE CELL
卷 15, 期 1, 页码 37-45出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E03-03-0191
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- NIGMS NIH HHS [R01 GM056312, R01-GM56312-01] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM056312] Funding Source: NIH RePORTER
The centrosome in animal cells provides a major microtubule-nucleating site that regulates the microtubule cytoskeleton temporally and spatially throughout the cell cycle. We report the identification in Drosophila melanogaster of a large coiled-coil centrosome protein that can bind to calmodulin. Biochemical studies reveal that this novel Drosophila centrosome protein, centrosome protein of 309 kDa (CP309), cofractionates with the gamma-tubulin ring complex and the centrosome-complementing activity. We show that CP309 is required for microtubule nucleation mediated by centrosomes and that it interacts with the gamma-tubulin small complex. These findings suggest that the microtubule-nucleating activity of the centrosome requires the function of CP309.
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