期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 1, 页码 56-63出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.0301211
关键词
osteoporosis; programming; epidemiology; growth; bone mass
IGF-1 is a key growth factor during fetal life. Using DXA, we found that the concentration of IGF-1 in umbilical cord serum is strongly related to neonatal whole body bone mineral content, lean mass, and fat mass. However IGF-1 did not explain the relationships of maternal smoking, fat mass, and physical activity with neonatal bone mass. The study supports a direct role for circulating IGF-1 in growth of the fetal skeleton.
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