期刊
CATALYSIS COMMUNICATIONS
卷 9, 期 3, 页码 421-424出版社
ELSEVIER
DOI: 10.1016/j.catcom.2007.07.028
关键词
carboxylic acids; cinchonidine; enantioselective; fluorinated; heterogeneous catalyst; hydrogenation; palladium
The hydrogenation of trifluoromethyl substituted prochiral alpha,beta-unsaturated carboxylic acids has been studied over cinchona alkaloid modified palladium heterogeneous catalysts. Low enantioselectivities were obtained in the hydrogenation of all three test compounds, 2-trifluoromethylacrylic acid, 4,4,4-trifluoro-3-methyl-2-butenoic acid and (E)-4,4,4-trifluoro-3-phenyl-2-butenoic acid, respectively. Significant increase in the enantioselectivity, up to 43%, was obtained in the hydrogenation of 4,4,4-trifluoro-3-methyl-2-butenoic acid by using benzylamine as additive. The presented results showed for the first time the possibility of enantioselective hydrogenation of alpha-unsubstituted beta-disubstituted alpha, beta-unsaturated carboxylic acids in the cinchonidine modified palladium catalytic system, that resulted in optically enriched saturated acids having the chiral center in P position. (c) 2007 Elsevier B.V. All rights reserved.
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