First catalytic asymmetric synthesis of beta-amino-beta-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines

Proline-catalysed direct asymmetric carbon - carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding beta-(p-methoxyphenyl) amino-beta-polyfluoroalkyl ketones in high enantioselectivities ( up to 98% ee).