期刊
JOURNAL OF VIROLOGY
卷 78, 期 1, 页码 250-256出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.1.250-256.2004
关键词
-
类别
资金
- NCI NIH HHS [R01 CA71878, R01 CA071878] Funding Source: Medline
- NINDS NIH HHS [R01 NS043097, R01 NS43097] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA071878] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS043097] Funding Source: NIH RePORTER
Infectious entry of JC virus (JCV) into human glial cells occurs by receptor-mediated clathrin-dependent endocytosis. In this report we demonstrate that the tyrosine kinase inhibitor genistein blocks virus entry and inhibits infection. Transient expression of dominant-negative eps15 mutants, including a phosphorylation-defective mutant, inhibited both virus entry and infection. We also show that the JCV-induced signal activates the mitogen-activated protein kinases ERK1 and ERK2. These data demonstrate that JC virus binding to human glial cells induces an intracellular signal that is critical for entry and infection by a ligand-inducible clathrin-dependent mechanism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据