期刊
JOURNAL OF IMMUNOLOGY
卷 172, 期 1, 页码 282-291出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.1.282
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资金
- NIAID NIH HHS [AI 38474, AI 007313, AI 31126] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI038474, T32AI007313, R01AI031126, R01AI038474, R29AI031126] Funding Source: NIH RePORTER
Dendritic cells (DCs) are a heterogeneous population of APCs with critical roles in T cell activation and immune regulation. We report in this study the identification and characterization of a novel subset of DCs resident in skin-draining peripheral lymph nodes of normal mice. This subset of CD11c(high)CD40(high)CD8alpha(intermediate) ((int)) DCs expresses the collagen-binding integrin, alpha(1)beta(1), and the E-cadherin-binding integrin, alpha(3)beta(7). Although alpha(1)beta(1) and alpha(E)beta(7) are also expressed on CD11c(high)CD40(int)CD8alpha(high) lymphoid DCs, CD11c(high)CD40(high)CD8alpha(int) DCs demonstrate preferential integrin-mediated adhesion to collagen and fibronectin. This DC subset most likely acquires expression of these integrins in peripheral lymph node, as this subset is not found in the spleen or mesenteric lymph node, and recent DC migrants from the skin lack expression of alpha(1)beta(1) and alpha(E)beta(7) integrins. Resident CD40(high) DCs express alpha(1)beta(1) integrin and colocalize with collagen in lymph nodes.. When compared with CD11c(high)CD40(high)CD8alpha(int) DCs lacking expression of these integrins, the alpha(1)beta(1)(+)alpha(E)beta(7) DC subset exhibits more efficient formation of Ag-independent conjugates with T cells, and a decreased ability to acquire soluble Ag. Thus, the alpha(1)beta(1) and alpha(E)beta(7) integrins define a unique population of peripheral lymph node-derived DCs with altered functional properties and adhesive potential that localizes these cells to sites in lymph nodes where Ag presentation to T cells occurs.
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