期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 28, 期 1, 页码 159-166出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ijo.0802515
关键词
atherosclerosis; carotid arteries; children; longitudinal; triceps skinfold thickness; ultrasound; intima-media thickness
资金
- NHLBI NIH HHS [HL-38844] Funding Source: Medline
- NIA NIH HHS [AG-16592] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL038844, U01HL038844] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016592] Funding Source: NIH RePORTER
OBJECTIVE: Although obese children are at increased risk for coronary heart disease in later life, it is not clear if this association results from the persistence of childhood obesity into adulthood. We examined the relation of adiposity at various ages to the carotid intima-media thickness (IMT) at age 35 y. DESIGN: Prior to the determination of IMT by B-mode ultrasound, subjects ( 203 men, 310 women) had, on average, six measurements of body mass index (BMI) and triceps skinfold thickness (TSF) between the ages of 4 and 35 y. Mixed regression models for longitudinal data were used to assess the relation of these characteristics to adult IMT. RESULTS: Overall, adult IMT was associated with levels of both BMI and TSF (P<0.001), with the magnitudes of the associations with childhood adiposity comparable to those with adult levels of BMI and TSF. Furthermore, adult obesity modified the association between childhood adiposity and IMT: high IMT levels were seen only among overweight ( BMI &GE;95th percentile) children who became obese (BMI &GE;30 kg/m(2)) adults (P<0.01 for linear trend). In contrast, IMT levels were not elevated among ( 1) overweight children who were not obese in adulthood, or among ( 2) thinner children who became obese adults. CONCLUSIONS: These results emphasize the adverse, cumulative effects of childhood-onset obesity that persists into adulthood. Since many overweight children become obese adults, the prevention of childhood obesity should be emphasized.
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