期刊
NUCLEIC ACIDS RESEARCH
卷 32, 期 -, 页码 D196-D199出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkh043
关键词
-
资金
- Biotechnology and Biological Sciences Research Council [BEP17014] Funding Source: Medline
Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The GenTHREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.
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