期刊
NEUROIMAGE
卷 21, 期 1, 页码 15-26出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2003.08.024
关键词
myelo-architecture; cerebral cortex; cortical areas
资金
- NCRR NIH HHS [P41 RR13642] Funding Source: Medline
- NIMH NIH HHS [P20 MH65166, P01 MH52176] Funding Source: Medline
- NLM NIH HHS [5 R01 LM05639] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR013642] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [P20MH065166, P01MH052176] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [R01LM005639] Funding Source: NIH RePORTER
We describe an automatic and reproducible method to analyze the histological design of the cerebral cortex as applied to brain sections stained to reveal myelinated fibers. The technique provides an evaluation of the distribution of myelination across the width of the cortical mantle in accordance with a model of its curvature and its intrinsic geometry. The profile lines along which the density of staining is measured are generated from the solution of a partial differential equation (PDE) that models the intermediate layers of the cortex. Cortical profiles are classified according to significant components that emerge from wavelet analysis. Intensity profiles belonging to each distinct class are normalized and averaged to produce area-specific templates of cortical myelo-architecture. (C) 2003 Elsevier Inc. All rights reserved.
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