期刊
BIOMATERIALS
卷 25, 期 1, 页码 77-83出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(03)00475-7
关键词
nano-topography; fibroblasts; cytoskeleton; cell adhesion
资金
- Biotechnology and Biological Sciences Research Council [JF20604] Funding Source: Medline
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical method of producing nano-topography. This manuscript investigates human fibroblast response to 27 nm high nano-islands produced by polymer demixing. Cell spreading, cytoskeleton, focal adhesion and Rac localisation were studied. The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture. (C) 2003 Elsevier Ltd. All rights reserved.
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