期刊
CARDIOVASCULAR THERAPEUTICS
卷 27, 期 1, 页码 59-75出版社
WILEY-HINDAWI
DOI: 10.1111/j.1755-5922.2008.00069.x
关键词
Adiponecitn; biomarker; drug target; exercise; gender difference; inflammation
资金
- Macao Science and Technology Development Fund [029/2007/A2]
A large number of studies revealed that adiponectin, a protein secreted specifically by adipose tissue, exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. This 247-amino acid protein contains four differentiable domains and exists in five different configurations, which binds three kinds of receptors. The plasma adiponectin concentration is at amazing microgram level and the gender difference is very clear. Obese subjects showed decreased plasma level of adiponectin while exercise seems to restore it. Many researchers demonstrated that it could be a reliable biomarker for multiple diseases. However, there is controversy about its role in inflammation since its plasma concentration decreases in some inflammatory diseases and increases under some other inflammatory conditions. The signal transduction pathway is still not very clear yet. Could adiponectin be a promising drug target ?.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据