期刊
CRITICAL CARE MEDICINE
卷 32, 期 1, 页码 250-255出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.CCM.0000104946.66723.A8
关键词
ventilatory management; acute respiratory distress syndrome; ventilator-induced lung injury; lung-protective ventilation
Objective. To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome. Data Sources., Relevant, peer-reviewed, scientific literature and personal observations from clinical practice. Study Selection: Relevant experimental studies and high-impact observational and clinical trials of acute respiratory distress syndrome management. Data Extraction: Detailed review of information contained in published scientific work. Data Synthesis. Interactive discussions between the authors that culminated in our consensus view of appropriate management. Conclusions: Prevention of ventilator-induced lung injury while accomplishing the essential life-supporting roles of mechanical ventilation is a complex undertaking that requires application of principles founded on a broad experimental and clinical database and on the results of well-executed clinical trials. At the bedside, execution of an effective lung-protective ventilation strategy remains an empirical process best guided by integrated physiology and a readiness to revise the management approach depending on the individual's response.
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