期刊
NEUROIMAGE
卷 21, 期 1, 页码 463-472出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2003.09.015
关键词
everit-related fMRI; diffusion tensor imaging; perinatal stroke; negative BOLD response; visual system
Focal ischemic brain injury, or stroke, is an important cause of later handicap in children. Early assessment of structure-function relationships after such injury will provide insight into clinico-anatomic correlation and potentially guide early intervention strategies. We used combined functional MRI (MM) with diffusion tensor imaging (DTI) in a 3-month-old infant to explore the structure-function relationship after unilateral perinatal stroke that involved the visual pathways. With visual stimuli, fMRI showed a negative BOLD activation in the visual cortex of the intact right hemisphere, principally in the anterior part, and no activation in the injured hemisphere. The functional activation in the intact hemisphere correlated clearly with the fiber tract of the optic radiation visualized with DTL DTI confirmed the absence of the optic radiation in the damaged left hemisphere. In addition, event-related fMRI (ER-fMRI) experiments were performed to define the characteristics of the BOLD response. The shape is that of an inverted gamma function (similar to a negative mirror image of the known positive adult BOLD response). The maximum decrease was reached at 5-7 s with signal changes of - 1.7 +/- 0.4%. Thus, this report describes for the first time the combined use of DTI and event-related fMRI in an infant and provides insight into the localization of the AM visual response in the young infant and the characteristics of the BOLD response. (C) 2003 Elsevier Inc. All rights reserved.
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