期刊
ANNALS OF NEUROLOGY
卷 55, 期 1, 页码 113-118出版社
WILEY-LISS
DOI: 10.1002/ana.10782
关键词
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资金
- PHS HHS [A69900, A617586, A610125] Funding Source: Medline
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
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