4.4 Article

One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors

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GENETICS
卷 166, 期 1, 页码 631-635

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GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.166.1.631

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  1. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R56GM028220, R01GM028220] Funding Source: NIH RePORTER
  2. NIGMS NIH HHS [GM-28220] Funding Source: Medline

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In Saccharonyces cerevisiae, genes located at the telomeres mid the HM loci are subject to transcriptional silencing, Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing, when targeted to a silencer-defective HMR locus.

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