期刊
LUNG CANCER
卷 43, 期 1, 页码 1-5出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2003.08.024
关键词
lung cancer; gender; risk; smoking
资金
- NATIONAL CANCER INSTITUTE [R01CA063393] Funding Source: NIH RePORTER
- NCI NIH HHS [R01-CA-63393] Funding Source: Medline
Study objectives: To assess lung cancer risk of smoking women relative to that of equally smoking men. Methods: The study base was constituted by baseline CT screenings for lung cancer on 1202 women and 1288 men, at least 40 years of age and with at least 10 pack-years of cigarette smoking. The prevatence-odds (incidence-density) ratio contrasting women with men was calculated. Confoundings by age and the particulars of smoking history were controlled in logistic regression analysis. Results: For the prevalence-odds ratio contrasting women with men, upon control of age and smoking history, the point estimate was 2.7 and the 95% interval estimate 1.6-4.7. The diagnosed cancers were of equally 'aggressive' types between the two genders. Conclusions: At variance with evidence from cohort studies, this evidence from a screening experience calls for further consideration of the hypothesis that women are more susceptible to tobacco carcinogens than are men. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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