期刊
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
卷 18, 期 2, 页码 181-183出版社
WILEY
DOI: 10.1002/rcm.1312
关键词
-
The use of high-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) with sulphur-specific detection was investigated as a method for obtaining metabolite profiles for the drug omeprazole administered as a 1:1 mixture of S-32- and S-34-labelled material. Analysis based on the monitoring of the chromatographic eluent at either m/z 32 or 34 was not successful due to insufficient sensitivity caused by interferences from polyatomic ions. However, reaction of sulphur with oxygen in the hexapole collision cell, combined with monitoring at m/z 48 (for S-32) or m/z 50 (for S-34), provided a facile method for metabolite profiling. Detection of m/z 48 was superior in sensitivity to detection of m/z 50. Copyright (C) 2003 John Wiley Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据