期刊
RADIOLOGY
卷 230, 期 1, 页码 125-134出版社
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.2301020934
关键词
lung neoplasms, CT; lung neoplasms, metastases; radiofrequency (RF) abation
PURPOSE: To assess technical feasibility, efficacy, and complications of percutaneous computed tomography (CT)-guided transthoracic radiofrequency (RF) ablation for treating inoperable non-small cell lung cancer (NSCLC) and lung metastases. MATERIALS AND METHODS: Twenty-six patients with 27 NSCLCs and four patients with five lung metastases underwent RF ablation with cooled-tip electrodes with CT guidance. Patients were not candidates for surgery because of either advanced-stage disease (n = 20) and/or comorbid processes (n = 4) or refusal to undergo surgery (n = 6). The procedure was performed with the intent to cure in 10 (33%) patients with stage I tumors and as palliative therapy in 20 (67%) patients. Contrast material-enhanced CT was performed immediately, 1 month, and then every 3 months after RF ablation to evaluate the response to therapy. Time to death for each patient was calculated with Kaplan-Meier analysis, and the effect of tumor size and the extent of coagulation necrosis on time to death were determined. RESULTS: Complete necrosis was attained in 12 (38%) of 32 lesions; partial (>50%) necrosis, in the remaining 20 (62%) lesions. Tumor size was a major discriminator in achieving complete necrosis. Complete necrosis was attained in all six (100%) tumors smaller than 3 cm but only in six (23%) of 26 larger tumors (P < .05). Mean survival of patients with complete necrosis (119.7 months) was significantly better than that of patients with partial necrosis (8.7 months) (P < .01). There were three (in 30 patients, 10%) major complications, which included acute respiratory distress syndrome, and two pneurnothoraces that required thoracostomy. sCONCLUSION: RF ablation appears to be a safe and promising procedure for the treatment of inoperable NSCLC and metastases. (C)d RSNA, 2003.
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