期刊
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
卷 56, 期 1, 页码 128-131出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.TA.0000051934.96670.37
关键词
apoptosis; arthritis; articular; cartilage; cell death; female; fracture; histology; histomorphometry; human; internal fixation; male; open reduction; trauma
Background: In this study, we wished to determine whether chondrocyte death occurs after intra-articular fracture and might thus contribute to the development of posttramnatic arthritis. Methods: Articular fracture fragments were obtained from 30 patients and the terminal deoxynucleotide transferase-mediated dUTP nick-end labeling assay was used to identify dead or dying cells. Results: Dead or dying cells were identified in all fracture fragments, with an average rate of cell death of 35%. Rates of cell death greater than 90% were seen in 4 of the 30 specimens studied. Conclusion: Although rates of apoptosis in osteoarthritis have been reported to average 15%, the rate in this fracture population was more than twice this value (35%). The high rate of cell death noted here may help explain the occurrence of posttramnatic arthritis even in anatomically fixed intra-articular fractures.
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