期刊
CARDIOVASCULAR RESEARCH
卷 86, 期 2, 页码 236-242出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvq045
关键词
Angiogenesis; Cell therapy; Gene therapy; HIF-1; Hypoxia; Vascularization
资金
- American Diabetes Association [1-06-RA-121]
- NIH [R01-HL55338, P20-GM78494, P01-HL65608, N01-HV28180]
- Johns Hopkins Institute for Cell Engineering
- Chilean Ministry of Planning (MIDEPLAN)
- Department of Nephrology, School of Medicine, Pontificia Universidad Catolica de Chile
- DIVISION OF HEART AND VASCULAR DISEASES [N01HV028180] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL065608, R01HL055338] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM078494] Funding Source: NIH RePORTER
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据