期刊
CURRENT PHARMACEUTICAL DESIGN
卷 10, 期 18, 页码 2185-2192出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612043384178
关键词
cerebral circulation; newborn; K+ channels; endothelin; oxygen free radicals; brain injury
Increasing evidence implicates endothelin in the pathophysiological development of cerebral vasospasin. This review Summarizes background topics Such as the structures and biosynthesis of endothelins, the types of endothelin and their receptors. as well as their biological effects. Basic science and clinical observations supportive of the role of endothelins in the spasm associated with stroke and subarachnoid hemorrhage are presented. Similar basic science and clinical observations are presented regarding the role of endothelins in impaired cerebral hemodynamics following traumatic brain injury, cryogenic cortical lesion injury and fluid percussion brain inJury. The role of age ill file contribution of endothelin to impaired cerebral hemodynamics following fluid percussion brain injury is discussed. Finally, potential mechanisms for endothelin contributions to vasospasm following fluid percussion brain injury such as impaired K+ channel function are described.
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