期刊
PEDIATRIC INFECTIOUS DISEASE JOURNAL
卷 23, 期 1, 页码 S11-S18出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.inf.0000108188.37237.48
关键词
polymerase chain reaction detection; multiplex polymerase chain reaction; respiratory viruses; children; adolescents; national disease rates
Background. The epidemiology of community-acquired respiratory viruses at the Children's Hospital of Wisconsin between 1996 and 1998 was examined with molecular [multiplex (M) PCR] and standard virologic methods. Methods and results. A total of 3325 patients with lower respiratory infection (LRI) [bronchiolitis (42%), pneumonia (38%) and croup (12%)] were identified. It is estimated that 545 000 LRI hospitalizations occur each year in the United States in children younger than 18 years old (viral, 428 000; pneumonia, 221000; bronchiolitis, 222 000; croup, 65 000), including a continued increase in bronchiolitis hospitalizations (47.8/1000; <1 year). The most common viruses detected each year in hospitalized children included respiratory syncytial virus (A and B; 117 000), parainfluenza virus (PIV-1 and -2, 48 000; PIV-3, 18 000) and influenza (A and B, 39 000). With multiplex reverse transcription polymerase chain reaction (MPCR), different patient populations demonstrated different LRI epidemiology in relation to specific syndromes and viral causes. At least 21% of LRI hospitalizations were in children with significant medical problems. PIVs were detected much more frequently in immunocompromised children than in previously healthy children (33% vs. 16%). Similarly 15% of respiratory syncytial virus was detected between May and October, mostly in immunocompromised children. Influenza caused 19% of bronchiolitis in previously healthy children, and no virus could be reliably predicted based on clinical presentation, including wheezing. Of children hospitalized for LRI, 40% tested positive for the seven most common respiratory viruses by MPCR. Conclusions. Work is under way to expand the number of viruses detected by MPCR and to determine whether newly discovered viruses, such as human metapneumovirus, contribute to the burden of pediatric LRI hospitalizations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据