期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 286, 期 1, 页码 R31-R37出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00282.2003
关键词
orosensory positive feedback; control of food intake; motivation
类别
资金
- NIDCD NIH HHS [DC-00240, R01 DC000240-18, R03 DC004751-03, DC-04751] Funding Source: Medline
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC000240, R03DC004751] Funding Source: NIH RePORTER
Although taste can influence meal size and body weight, the neural substrate for these effects remains obscure. Dopamine, particularly in the nucleus accumbens, has been implicated in both natural and nonnatural rewards. To isolate the orosensory effects of taste from possible postingestive consequences, we investigated the quantitative relationship between sham feeding of sucrose and extracellular dopamine in the nucleus accumbens with microdialysis in rats. Sucrose intake linearly increased as a function of concentration (0.03 M, 18.07 +/- 2.41 ml; 0.1 M, 30.92 +/- 2.60 ml; 0.3 M, 43.28 +/- 2.88 ml). Sham feeding also stimulated accumbens dopamine overflow as a function of sucrose solution concentration (0.03 M, 120.76 +/- 2.6%; 0.1 M, 140.28 +/- 7.8%; 0.3 M, 146.27 +/- 5.05%). A second experiment used the same protocol but clamped the amount of sucrose ingested and revealed a similar, concentration-dependent dopamine activation in the nucleus accumbens. This is the first demonstration of a quantitative relationship between the concentration-dependent rewarding effect of orosensory stimulation by sucrose during eating and the overflow of dopamine in the nucleus accumbens. This finding provides new and strong support for accumbens dopamine in the rewarding effect of sucrose.
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