期刊
CARDIOVASCULAR RESEARCH
卷 82, 期 2, 页码 286-295出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvn283
关键词
Ischaemia; reperfusion; Heart failure; Atrial fibrillation
资金
- Australian National Health and Medical Research Council [418935, 317803]
- Baker IDI Heart and Diabetes Institute
Arrhythmias arise from a complex interaction between structural changes in the myocardium and changes in cellular electrophysiology. Electrophysiological balance requires precise control of sarcolemmal ion channels and exchangers, many of which are regulated by phospholipid, phosphatidylinositol(4,5)bisphosphate. Phosphatidylinositol(4,5)bisphosphate is the immediate precursor of inositol(1,4,5)trisphosphate, a regulator of intracellular Ca2+ signalling and, therefore, a potential contributor to arrhythmogenesis by altering Ca2+ homeostasis. The aim of the present review is to outline current evidence that this signalling pathway can be a player in the initiation or maintenance of arrhythmias.
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