期刊
DEVELOPMENTAL DYNAMICS
卷 229, 期 1, 页码 143-161出版社
WILEY
DOI: 10.1002/dvdy.10444
关键词
hindbrain; motor neuron; rhombomere; axon guidance; anatomy; specification; neuronal migration; branchial arch; cranial; segmentation
资金
- NINDS NIH HHS [R56 NS040449, R01 NS040449-03, R01 NS040449, NS40449] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R56NS040449, R01NS040449] Funding Source: NIH RePORTER
The cranial motor neurons innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. These efferent neurons develop at characteristic locations in the brainstem, and their axons exit the neural tube in well-defined trajectories to innervate target tissues. This review is focused on a subset of cranial motor neurons called the branchiomotor neurons, which innervate muscles derived from the branchial (pharyngeal) arches. First, the organization of the branchiomotor pathways in zebrafish, chick, and mouse embryos will be compared, and the underlying axon guidance mechanisms will be addressed. Next, the molecular mechanisms that generate branchiomotor neurons and specify their identities will be discussed. Finally, the caudally directed or tangential migration of facial branchiomotor neurons will be examined. Given the advances in the characterization and analysis of vertebrate genomes, we can expect rapid progress in elucidating the cellular and molecular mechanisms underlying the development of these vital neuronal networks. (C) 2003 Wiley-Liss, Inc.
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