期刊
CARDIOVASCULAR DRUGS AND THERAPY
卷 25, 期 5, 页码 495-500出版社
SPRINGER
DOI: 10.1007/s10557-011-6325-5
关键词
Atherosclerosis; Coronary artery disease; Hypertension; Myocardial ischemia; LOX-1; Oxidative stress
There is much interest in the role of oxidant stress in an ever-increasing list of disease states. However, the precise mediator of oxidant stress and the stressor molecule/s have not been identified. Accordingly, trials of inhibitors of oxidant stress in animal models of disease states have met only limited success. The trials of traditional anti-oxidant vitamins have been largely unsuccessful in the treatment of a wide array of disease states in humans. Recent identification of LOX-1 in vascular endothelial cells and its activation by oxidant species have led to a marked improvement in our understanding of the pathology of several cardiovascular disease states. Here, we review the disease states where therapy targeted at LOX-1 inhibition might be helpful.
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