期刊
CARDIOVASCULAR DIABETOLOGY
卷 17, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12933-018-0766-0
关键词
Atherogenesis; Cardiovascular risk reduction; Coronary artery disease; Dyslipidemia; Hypertriglyceridemia; Omega 3 supplements; Polyunsaturated fatty acids; Type 2 diabetes mellitus
There is a vast disagreement in relation to the possible beneficial effects of omega-3 polyunsaturated fatty acids (omega-3 PUFA) supplementation in patients with diabetes and cardiovascular disease. The conflicting results between the various original studies and meta-analyses could be partially explained as a result of variable supplementation dosage and duration, either of which may modify the effects of omega-3 PUFA on cardio-metabolic biomarkers. Meta-analyses are limited usually by the inability to draw inferences regarding dosage, duration and the interaction of dosage and duration of omega-3 PUFA intake. Even so, almost all endpoints in the so-called negative meta-analyses leaned toward a trend for benefit with a near 10% reduction in cardiovascular outcomes and a borderline statistical significance. Many trials included in these meta-analyses tested an insufficient daily dose of omega-3 PUFA of less than 1000 mg. Probably, the consistent cardiovascular effects of omega-3 PUFA supplements could be expected only with daily doses above 2000 mg.
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