期刊
THROMBOSIS RESEARCH
卷 114, 期 5-6, 页码 559-571出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2004.06.002
关键词
antibody; cardiolipin; consensus; ELISA; guideline; phospholipid; recommendation; standardization
Despite the use of standardized GPL and MPL units, significant inter-laboratory and inter-method variation in anticardiolipin antibody (aCL) testing still exists, Limiting the clinical utility and inter-laboratory portability of test results. This article reviews published and unpublished guidelines (some developed using consensus procedures) that can be used to improve various aspects of: (1) specimen collection; (2) aCL assay manufacture and testing procedures; (3) quality control; and (4) interpretation (including reporting) of results; and in doing so, improve the consistency of aCL results between different laboratories, assays and runs. However, there is a stilt a need for consensus guidelines that combine and deal with all of the aforementioned aspects of aCL testing and reporting. (c) 2004 Elsevier Ltd. All rights reserved.
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