期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 9, 期 -, 页码 619-631出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1095
关键词
FKBP12; TGF-beta; type I receptor; type II receptor; farnesyltransferase; review
FKBP12 as an immunophilin that binds to two well-known immunosuppressive macrolides, FK506 and rapamycin, has attracted immense attention and its role in mediating the immunosuppressive functions of these macrolides has been extensively studied. Since FKBP12 is a well-conserved protein among many species and is also highly expressed in almost all cells, it must play important roles in cellular function in the absence of macrolides. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multiprotein complex formation. This review summarizes another physiological role of FKBP12 as an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a guardian for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular gradient reader for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts.
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