期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 27, 期 1, 页码 106-110出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02980055
关键词
Acanthopanax senticosus; Araliaceae; s-transaminases CCl4-intoxication; antioxidant enzymes; eleutheroside B; eleutheroside E; DPPH
The antioxidant activities of Acanthopanax senticosus stems were evaluated in CCl4-intoxicated rats. The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. The n-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by CCl4-intoxication. Eleutheroside B, a lignan component, isolated from the n-butanol fraction was found to cause a moderate free radical scavenging effect on DPPH, its scavenging potency as indicated in IC50 value, being 58.5 muM These results suggested that the stems of A. senticosus possess not only antioxidant but also hepatoprotective activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据